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Good morning, ladies and gentlemen, and welcome to the ADC Therapeutics Q2 2026 Earnings Conference Call. At this time, all lines are in listen-only mode. Following the presentation, we will conduct a question-and-answer session. If at any time during this call you require immediate assistance, please press star zero for the operator. This call is being recorded on Thursday, August 13, 2026. I would now like to turn the conference over to Nicole Riley, Head of Investor Relations and Corporate Communications. Please go ahead. Thank you, Operator. Today, we issued a press release announcing our second quarter 2026 financial results and business updates. This release and the slides we will use in today's presentation are available on the Investor section of the ADC Therapeutics website. I'm joined on today's call by our Chief Executive Officer, Amit Malik, who will discuss our operational performance and recent business highlights, followed by our chief medical officer, Mohamed Zaki, who will provide clinical and regulatory updates. And lastly, our chief financial officer, Pepe Carmona, who will review our second quarter 2026 financial results. We will then open the call to questions. Before we begin, I would like to remind listeners that some of the statements made during this conference call will contain forward-looking statements within the meaning of the safe harbor provisions of the U.S. Private Securities Litigation Reform Act of 1995. These forward-thinking statements are subject to certain known and unknown risks and uncertainties, and actual results, performance, and achievements could differ materially. They are identified and described in the accompanying slide presentation and in the company's filings with the SEC, including Form 10-K, 10-Q, and 8-K. ADC Therapeutics is providing this information as of today's date and does not undertake any obligation to update any forward-looking statements contained in this conference call as a result of new information, future events, or circumstances, except as required by law. The company cautions investors not to place undue reliance on these forward-thinking statements. Today's presentation also includes non-GAAP financial reporting. These non-GAP measures should be considered in addition to, and not in isolation or as a substitute for, the information prepared in accordance with GAAP. You should refer to the company's second quarter 2026 earnings release for information and reconciliation of historical non- GAAP measures to the comparable GAAP financial measures. I will now turn the call over to our CEO, Amit Malik. Amit? Thank you, Nicole. We are pleased to share that Zinlanta's commercial performance in the second quarter of 2026 continued to be broadly in line with recent quarters. We remain confident in the roles Zinlantha will continue to play as a differentiated single-agent treatment option for third-line plus DLBCL patients. Turning to our pipeline progress, as previously disclosed, we announced top-line results for Lotus 5 in June. Based on this data, we held a pre-SVLA meeting with the FDA, and following the meeting, we are assessing the best regulatory path forward. Mohamed will share more details regarding the FDA feedback and our regulatory strategy. Further to this, the full Lotus 5 data have now been submitted for presentation at ASH, and we are preparing to submit for publication with compendia submission to follow. For Lotus 7, we were pleased to complete enrollment of 100 patients at the selected dose level of Xenlanta plus clofidamab as shared in June and have submitted an abstract to ASH for presentation of the data, which we continue to believe demonstrates the most compelling combination data generated to date in second-line plus DLBCL, with a safety profile generally consistent with prior Lotus 7 disclosures. With these data, we believe that Zynlanta plus clofidamab offers an opportunity to take a leading second-line position in the context of the evolving competitive landscape, solidifying Zynlantha as a foundational therapy in DLBCL. Beyond this, we are preparing to submit for publication of the LOTUS-7 data with compendia submission to follow. Simultaneously, we're exploring the potential regulatory pathway for this combination and expect to submit a breakthrough designation this year. With respect to the multicenter investigator-initiated trials of Zolanta in indolent lymphomas, updated marginal zone lymphoma data was submitted to ASH with publication and compendia submission to follow. Presentation of updated follicular lymphoma data is anticipated in the second quarter of 2027 with publication and compenda submission to follow, we also intend to assess potential regulatory pathways for these endo-lymphomas and expect to submit for a breakthrough designation for MZL. Moving now to corporate updates. We announced a strategic reorganization in June. As part of this, we implemented a reduction in our workforce of approximately 17%, as well as additional operational efficiencies, resulting in cost savings of approximately $10 million on an annualized basis. As shared at that time, with these changes, we are a resource to deliver on our key clinical, regulatory, and manufacturing activities while maintaining the full externally facing footprint to support the continued commercialization of Zenlanta in the Third Line Plus DLV CL setting. Finally, we ended the second quarter of 2026 with a healthy cash balance of $219.1 million, maintaining our expected cash runway at least into 2028 and enabling us to deliver against our strategy. Now, we'd like to take a moment to remind everyone of our strategy to grow Zinlanta. Currently, Zinranta plays a clear role in the third-line plus DLBCL setting. As monotherapy, ZINRANTA has a well-established profile of rapid, deep, and durable efficacy, as well as manageable safety with simple and convenient administration. Since FDA accelerated approval in 2021, ZInranta monotherapy has been used in treating approximately 5,000 patients in the U.S. We believe this is just a starting point as we see the potential for Zolanta to reach significantly more patients by expanding use into earlier allowance of therapy in DLBCL and into indolent lymphomas. Now I would like to turn the call over to Mohamed, our CMO, to share more on our pipeline. Thank you, Amit. I would now like to share more on our LUTAS-5 and LUTAs-7 studies as we continue to work towards expansion of the NLONTA in earlier lines of DLBCL. As a reminder, LUTas-5 is our phase 3 confirmatory study of the LONTA, in combination with rituximab versus Argemux, in patients with second-line DBCL, which recently read out and met the primary endpoint of progression-free survival. As noted, we held a meeting with the FDA in early August to present and discuss the totality of the LUTUS-5 data along with the potential regulatory pathway. During this meeting, the FDA noted substantial concerns regarding the benefit risk or verification of clinical benefit observed in LUTF-5 trials. As such, the company is now assisting the regulatory path forward. We plan to provide an update on regulatory strategy and timing in the future. Beyond this, the data has been submitted to ASH. We are simultaneously pursuing publication for LUTAS-5 and potential compendia inclusion starting in 2027. Turning now to LUTAs-7, our Phase 1b trial combining Zolanta with the highly effective bispecific glufetamab in second-line plus DLGCL patients, we recently announced completion of enrollment of 100 patients at the 150 micrograms per kick dose. Of note, consistent with other glufitamab trials, the protocol for LUTF-7 recommends prophylaxis, including vaccination for virus, fungal, and bacterial infections, including PGP and Herb's Fires, which was not part of the Lotus 5 protocol. Here, we continue to be encouraged by the promising Lotus 7 data shared to date, which we believe demonstrates the potential force in LONTA plus Glopitamab to be the best in-class combination. with data on larger number of patients with longer follow-up has been submitted to ASH for presentation. This data supports the company's belief that the Lanta plus Glufidamab demonstrates the most compelling combination data generated to date in second-line DLBCL with a safety profile generally consistent with prior Luta7 disclosures. separately we are preparing for submission of the full 27 data for publication and following that plan to submit to compendia for potential inclusion starting in 2027. in addition based on this potentially practice changing the seven data the company plans to submit for breakthrough designation this year and is assessing a phase three trial for the the combination of Xenolonta plus Grufitamab. Moving forward, we plan to work closely with the FDA to determine the best path forward to achieve the full approval and advance Xenononta combinations into earlier lines of therapy in DL-BCL. In the meantime, we remain confident that Xenontonta will continue to play a meaningful overall for patients with B-cell malignancies within its currently approved third-line plus DL-BCL settings. With that, I would like to turn the call over to Patrick Tarmano, our CFO. Thank you, Mohamed. On the financial front, Zimontanet product revenues in the second quarter of 2026 were $18.6 million as compared to $181 million in the same quarter in 2025. Cost of product sales was $2.3 million and $6 million for the second quarter, and six months ended June 30, 2026, as compared to $0.8 million and $2,9 million for same periods in 2025. The increases compared to prior year are primarily driven by a changing focus of personnel from research and development clinical supply activities to commercial manufacturing activities. Total operating expenses were $44.7 million for the second quarter. On a non-GAAP basis, total adjusted operating expenses were $37.2 million for a quarter and were down by 22% over the prior year, primarily driven by lower R&D expenses. As Hamid noted, we expect to save an additional $10 million on an annual basis as a result of the strategic reorganization we announced in June. On a gap basis, we reported a net loss of $16.6 million for the second quarter of 2026 as compared to a net lost of $56.6 billion for the same period in 2025. The second quarterof 2026 included a one-time expense related to the strategic reorganization, while the year-ago quarter included restructuring, impairment, and related costs from the June 2025 Strategic Reprioritization and Restructuring Plan. On a non-GAAP basis, the adjusted net loss was $16.3 million for the second quarter of 2026 as compared to a net loss of $28.7 million for same period in 2025. The lower net loss on a non-GAAP basis was primarily due to lower operating expenses. The year-over-year changes on a per-share basis were additionally impacted by the higher number of weighted average shares outstanding. You can find the reconciliation of GAAP to non-GaAP measures for the second quarter in the accompanying financial tables of the press release issued earlier today and in the appendix of this presentation. At the end of the second quarter, we had cash equivalence of $219.1 million as compared to $231 million of March 31st, 2026, a change primarily driven by cash use in operations. This provides us with an expected cash runway at least into 2028. With that, I will turn the call back over to Amit. Thank you, Pepe. To close, we are pleased by the commercial performance and the role that Xenlanta monotherapy continues to play in third-line plus DLBCL. We look forward to presentation of data from LOTUS-5, LOTUS 7, and MZL before year-end with publication and potential companion inclusion to follow. Following the FDA pre-SBLA meeting, we are assessing regulatory approaches to determine the best path forward for the LOTUS 5 trial. At the same time, we believe we have an opportunity for Zynlanta plus clofidamab to take a leading second-line position in DL-BCL as a potential best-in-class bispecific combination and are actively assessing the potential regulatory path forward. Together, we anticipate we can grow ZynLanta beginning in 2027 as we work to make a meaningful difference in the lives of many more patients with B-cell malignancies. We can now open the line for questions. Operator? Thank you. Ladies and gentlemen, we will now begin the question and answer session. Should you have a question, please press the star followed by the 1 on your touchtone phone. You will hear a prompt that your hand has been raised. Should you wish to decline from the polling process, please push the star. Please press the start followed by a 2. If you are using a speakerphone, please lift the handset before pressing any key. One moment, please, for your first question. Your first question comes from Eric Smith with Cantor. Please go ahead. Thanks for taking my question. I appreciate all the updates. Maybe just on the status of the current accelerated approval for Zinlanta, given the questions around risk-benefit from Lotus 5, was there any FDA discussion of maintaining that accelerated approval status? Yeah, it's a great question. So, first of all, all the discussions with the FDA were related only to the trial. All their comments were specific to the combination of Simonda plus rituximab on the trial, so there was no feedback at all about the single agent. So, we remain confident that the monotherapy will stay on the market, will continue to have a fair approval, and we're committed to working with the USDA to make sure that we can satisfy the full approval, either through Lotus 5 or through another study group. Thank you, Amit. And then on Lotus 7 and your characterization of the most recent efficacy data that you guys have seen is compelling and consistent in safety. Have you essentially now seen the final ASH presentation and do your comments pertain to that? In other words, do you know exactly what you'll present Is it consistent with that statement? Yeah, so we've already submitted the abstract for ASH, which contains, obviously, the vast majority of the 100 patients that we enrolled. So the belief that I'm sharing with you about the fact that we think we have very compelling efficacy and safety data is reflective of that ASH abstract, where obviously, for disclosure reasons, you can imagine we don't want to share all the details, but we do believe that we have very compelling data, both from an efficacy and a safety standpoint, within the Lotus 7 data that was submitted to ASH. Thank you. And one more question, if I may, with regard to exploring a Phase 3 pathway for the combination in Lotus 7. Is that something you're exploring with Roche or by yourselves? Yeah, I don't want to comment on that. Obviously, we have a great partnership with Roache, and they've given us great feedback throughout. But what I would say is we've had lots of discussions, but also lots of thought, as you can imagine, even independent of the feedback we have today, about a potential phase three design because we know that this data is so compelling that there could be significant upside to the asset by potentially pursuing phase three assets. So it's something we've been thinking about for a long time. The team has already been preparing on different design options that we do plan to file for a breakthrough designation this year and to discuss with the FDA potential designs. Thank you for taking my questions. Yeah, thank you, Eric. Your next question comes from Michael Schmidt with Guggenheim Securities. Please go ahead. Hey, this is Sarah on for Michael. Thanks so much for taking the time to talk to me. Thank you so much. Thank you very much for asking my question. Just wanted to follow on quickly on the Phase 3 plans, whether you could give any color on sort of timeline for that now that it appears to be sort of more of the future looking focus and then additionally had a sort of a question on the Lotus 5 data so I know you've mentioned the 105 day period for monitoring adverse events after after treatment I was wondering if you could comment on the timing of the deaths So, first of all, I just want to emphasize, we have a positive study for LOTUS V. So, we still are assessing possibilities to identify the best regulatory approach for LOTUs V. I mean, specifically, we're considering whether additional data, risk management options, or modifications to the potential label can address the update concerns of LOTUS VI. So, we are doing that. In parallel, given that we have, you know, we think potentially practice changing data on hand with the Lotus 7, we're also in parallel going to file for breakthrough designation and explore a phase 3 approach there. So it's too premature at this point, as you can imagine, while we're still gathering inputs from the medical community, and obviously I have to collaborate with the FDA on the final design to talk about timing and cost, but I just want to reemphasize that those two things are going in parallel. And then with regards to the 105-day safety window, in terms of capturing AEs post-Alaska, That's the same, by the way, in Lotus 7 as well. And one thing I want to emphasize is that, as Mohamed mentioned on the call, there was a big difference between Lotus 5 and Lotus 7, particularly with regards to the prophylactic measures taken. So, in lotus 7, consistent with a lot of the other – with the other glorified trials that have been run, in lotus 7 recommends prophylaxis, including vaccinations for viral, fungal, and bacterial infections. That was not part of the lotus 5 protocol. So while the time period that we're capturing AEs is very similar, there was a pretty big difference in terms of prophylaxis in the protocol between 5 and 7. Appreciate it. Thank you. Thank you, Sarah. Your next question comes from Mari Raycraft with Jefferies LLC. Please go ahead. Hi. Good morning. This is James on for morning. Thanks for taking our questions. Can you provide more detail on the type of grade 5 infections that were observed in Lotus 5 and whether those events would have been expected to be mitigated by the prophylactic and vaccination strategies now incorporated into Lotus 7? Did other infections occur that aren't addressed by those vaccines? And I have thought well back to that. Yeah, so the primary type of infections were bacterial, which is why we think that prophylactics could play a role. Got it. And how do you think about the potential read-through from LOTUS 5, grade 5 signal to potential NCC compendia inclusion and adoption of the dinlantaglifidamab combination within the academic community? Could the LOTUS impact the NCC language, and could there be any safety monitoring requirements? I don't think there will be any read-thru in terms of LOTUS 7 compendium including two very different studies um two different regimens and as i mentioned the protocol is is different which we think can help to contribute to some of the safety differences just as a reminder obviously i can't speak to the data we have on hand but i can speak to the prior disclosure that we had we had a very low percent of grade five events approximately four percent if you look at our last disclosure we had in december on the 49 patients that we recorded so i do think there's a there's There's a difference that we don't think that would be a read-through to Lotus 7 or to any, you know, potential NCCN or any inclusion. Very helpful. Thank you. Thank you, Richard. You now have a question from Leonard Timishis with RBC Capital Markets. Please go ahead. Hi, guys. Josh on for Leo here. Thanks for taking my question. I was wondering whether or not the FDA, in their feedback in response to the Phase III roundup, did they provide any kind of indication of what an effective path forward might look like and what strategies you guys are thinking about at the time being? Thanks. Yeah, and I think, you know, typical in what you'd have in the pre-SBLA meeting, we share the data results and you're aligning on the package for an SBLA submission. During that, as is typical with any other PSVLA meeting, they share concerns that they have with the data. And so, right now, we're basically, you know, going through the feedback and assessing whether additional data risk management options or modifications to the potential label can help to address those FDA concerns. And that's the basis of which we're evaluating our path forward for those five. Thanks, Chris. Thank you. As a reminder, if you wish to ask a question, please press star followed by the one. Your next question comes from Rob Burns with HC Wainwright. Please go ahead. Hi, this is Ahmed on for Rob. Thank you for taking our questions. I was just wondering if you saw 2Q product revenue increase versus 2Q25. And I was wondering if you've seen any changes in patient starts or unit demand dosing or physician prescribing behaviors and slow despite disclosure. And then for my second question, I was wandering if in your conversations with the FDA, did they focus on the PFS in patients 75 or older, and if that would influence eligibility criteria or future label? Thank you. Yeah, so with regard to scale, we haven't seen any impact. If you look at the volume in Q2, it's very consistent with prior quarters. And we don't think that there will be. If you looked overall over the past several quarters, the commercial performance of the monotherapy in the third line plus setting has been relatively consistent. And that's because demand has established place in that third line top setting, and we don'T expect any impact on monotherapy sales. And then remind me again, I'm sorry, your second question. No problem. I'm 75 or older, right? Yes, thank you. Yeah. We don't think it will have any impact on other studies. You know, I think, obviously, you know, older patients, specifically with infection, we think that the prophylaxis, you know, can play a role. And that's also why the protocol, again, I want to stress the low to 7 versus low to 5 are quite different. So I think each study is on its own. You know? I don't know that there's a read-through on this. We certainly learned a lot from MODIS 5 and we're happy with the differences in the protocol, of course, that we're seeing in MODIS 7. So, we don't see any reason for MODIS 5 to either the current indication or other potential combinations. Thank you. There are no further questions at this time. So, I will now turn the call over to Amit Malek for closing remarks. Please continue. Well, thank you all for joining the call today and for your continued support. We look forward to keeping you updated on our progress. Operator, you may now end the call. Ladies and gentlemen, this concludes today's conference call. Thank you for your participation. You may now disconnect.